Hydrochlorothiazide: The commonest signs and signs and symptoms of overdose noticed in humans are Those people a result of electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from too much diuresis.
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Pregnancy Category D. Usage of medicine that act about the renin-angiotensin program in the course of the second and 3rd trimesters of pregnancy reduces fetal renal function and improves fetal and neonatal morbidity and Dying.
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Inhibition of SLC12A3 decreases the magnitude with the concentration gradient concerning the epithelial mobile and distal convoluted tubule, reducing the reabsorption of drinking water.
Nursing Moms: It's not recognised no matter if irbesartan is excreted in human milk, but irbesartan or some metabolite of irbesartan is secreted at low concentration from the milk of lactating rats.
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